HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 510880Generated: October 31, 2026
Ammonia → 3'-Acetyl-5'-chloro-3-fluoro-2'-methoxy-6'-methylbiphenyl-4-carboxamide
https://huagongshe.com/reaction/510880
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Methyl 3'-acetyl-5'-chloro-3-fluoro-2'-methoxy-6'-methylbiphenyl-4-carboxylate | HCID 86666801 | — |
| Product | 3'-Acetyl-5'-chloro-3-fluoro-2'-methoxy-6'-methylbiphenyl-4-carboxamide | HCID 86666802 | — |
Reaction Steps
A mixture of methyl 3′-acetyl-5′-chloro-3-fluoro-2′-methoxy-6′-methylbiphenyl-4-carboxylate (25 mg, 0.071 mmol) and 7.0 M ammonia in methanol (2.0 mL, 14 mmol) was heated at 90° C. in a sealed tube overnight. After evaporating the mixture to dryness, the residue was used directly in next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09096600B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-784d7d025b124da5bc67389bc504ba88 |
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| Source note | uspto-grants-2015_08 |
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