反应详情

1-{5-Chloro-3-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-2-methoxy-4-methylphenyl}ethanone (0.22 g, 0.65 mmol) was treated with 1.0 M hydrogen chloride in water (3.9 mL, 3.9 mmol) in tetrahydrofuran (4 mL) overnight. The mixture was quenched with saturated sodium bicarbonate and extracted with ethyl acetate. The organic layers were dried over MgSO4, filtered, concentrated and purified on silica gel (eluting with 0-60% of ethyl acetate in hexane) to afford the desired product (0.13 g, 75%). LCMS calculated for C13H14ClN2O2 (M+H)+: m/z=265.1. found: 265.0.

1. customThe mixture was quenched with saturated sodium bicarbonate
2. extractionextracted with ethyl acetate
3. dry with materialThe organic layers were dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated
6. custompurified on silica gel (eluting with 0-60% of ethyl acetate in hexane)