2-Tert-Butylphenol → (2R)-7-(3-(2-Chloro-4-tert-butylphenoxy)propoxy)-2-methylchromane-2-carboxylic Acid

HRID 51092Notes

Reaction equation

HRID 51092 reaction equation
[C:1](C1C=CC=CC=1O)(C)(C)C.[Cl:12][C:13]1[CH:37]=[C:36]([CH:38]2[CH2:43]CCC[CH2:39]2)[CH:35]=[CH:34][C:14]=1[O:15][CH2:16][CH2:17][CH2:18][O:19][C:20]1[CH:29]=[C:28]2[C:23]([CH2:24][CH2:25][C@:26]([CH3:33])([C:30]([OH:32])=[O:31])[O:27]2)=[CH:22][CH:21]=1>>[Cl:12][C:13]1[CH:37]=[C:36]([C:38]([CH3:43])([CH3:1])[CH3:39])[CH:35]=[CH:34][C:14]=1[O:15][CH2:16][CH2:17][CH2:18][O:19][C:20]1[CH:29]=[C:28]2[C:23]([CH2:24][CH2:25][C@:26]([CH3:33])([C:30]([OH:32])=[O:31])[O:27]2)=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 69232-Tert-ButylphenolHCID 10182946(2R)-7-(3-(2-Chloro-4-cyclohexylphenoxy)propoxy)-2-methylchromane-2-carboxylic Acid

Product 1

HCID 10113686(2R)-7-(3-(2-Chloro-4-tert-butylphenoxy)propoxy)-2-methylchromane-2-carboxylic Acid

Procedure

The title compound was prepared following the procedures described in Example 5, Step B-E employing tert-butylphenol instead of 4-(2,2,2-trifluoroethoxy)phenol, and (2R)-methyl 2-methyl-7-hydroxychromane-2-carboxylate (Example 23, Step A) instead of ethyl 2-ethyl-7-hydroxychromane-2-carboxylate.

Sources & evidence

ORD record
ord-3448a21a844243a6886e07a4cdd6700f
Source dataset
uspto-grants-2004_03
Patent number
US06713508B2

Reaction notes

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