Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 86666927 | HCID 86666927 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86666929 | HCID 86666929 | 8% |
Reaction Steps
N-[1-(5-chloro-2-methoxy-4-methyl-3-oxiran-2-ylphenyl)ethyl]-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (140.0 mg, 0.32 mmol) was stirred in methylene chloride (1.1 mL). Isopropylamine (124 μL, 1.6 mmol) and DIPEA (282 pt, 1.62 mmol) were added. The mixture was stirred at 80° C. overnight. Methanol was added and purification by preparative LC/MS (pH 10) gave the desired compound (12.9 mg, 8%). LCMS calculated for C25H36ClN6O3 (M+H)+: m/z=503.3. found: 503.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09096600B2 |
|---|
| Source dataset | uspto-grants-2015_08 |
|---|
| ORD ID | ord-f0d3e3ed1a43414886950643ed45a152 |
|---|
| Source note | uspto-grants-2015_08 |
|---|
