HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 11095658, compound → HCID 86670526, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 11095658 | HCID 11095658 | — |
| Reactant | (8S,11R,13S,14S,17S)-17-hydroxy-11-[4-((RS)-1-hydroxyethyl)phenyl]-1 3-methyl-17-pentafluoroethyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | HCID 18346565 | — |
| Product | HCID 86670526 | HCID 86670526 | 91% |
Reaction Steps
In analogy to Example 5, 400 mg (0.78 mmol) of (8S,11R,13S,14S,17S)-17-hydroxy-11-[4-((RS)-1-hydroxyethyl)phenyl]-13-methyl-17-pentafluoroethyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one were converted using (S)-2-allyloxycarbonylamino-3-methylbutyric acid and, after workup and purification, 495 mg (91%) of the title compounds were isolated as a colourless foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096639B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-61bd4ccbb1a44c0f8556f6f8dd91265e |
| Source note | uspto-grants-2015_08 |