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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 511050Generated: November 1, 2026

HCID 11095658, compound → HCID 86670526, compound

https://huagongshe.com/reaction/511050

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 11095658HCID 11095658—
Reactant(8S,11R,13S,14S,17S)-17-hydroxy-11-[4-((RS)-1-hydroxyethyl)phenyl]-1 3-methyl-17-pentafluoroethyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-oneHCID 18346565—
ProductHCID 86670526HCID 8667052691%

Reaction Steps

In analogy to Example 5, 400 mg (0.78 mmol) of (8S,11R,13S,14S,17S)-17-hydroxy-11-[4-((RS)-1-hydroxyethyl)phenyl]-13-methyl-17-pentafluoroethyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one were converted using (S)-2-allyloxycarbonylamino-3-methylbutyric acid and, after workup and purification, 495 mg (91%) of the title compounds were isolated as a colourless foam.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09096639B2
Source datasetuspto-grants-2015_08
ORD IDord-61bd4ccbb1a44c0f8556f6f8dd91265e
Source noteuspto-grants-2015_08