HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 511072Generated: November 1, 2026
Sodium Hydroxide → [1-(4-Trifluoromethyl-phenyl)-piperidin-4-yloxy]-acetic acid tert-butyl ester
https://huagongshe.com/reaction/511072
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | tert-Butyl bromoacetate | HCID 79177 | — |
| Reactant | 1-[4-(Trifluoromethyl)phenyl]piperidin-4-ol | HCID 22097674 | — |
| Catalyst | Tetrabutylammonium Bromide | HCID 74236 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | [1-(4-Trifluoromethyl-phenyl)-piperidin-4-yloxy]-acetic acid tert-butyl ester | HCID 58576326 | — |
Reaction Steps
Tetrabutylammonium bromide (275 mg; 0.85 mmol) is added to a solution of the crude 1-(4-trifluoromethyl-phenyl)-piperidin-4-ol (627 mg, prepared in accordance with Example 9) in toluene (8 mL). The reaction mixture is cooled to 0° C. and aq. 35% sodium hydroxide (8 mL) is added followed by a drop wise addition of tert-butyl bromoacetate (749 mg; 3.84 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09096524B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-7388af2873234ecb98ac2e46728b7e1d |
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| Source note | uspto-grants-2015_08 |
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