4-(Phenylsulfonyl)aniline → (4-Benzenesulphonyl)phenyl-(6-iodo-7-fluoro-quinazolin-4-yl)-amine hydrochloride

HRID 51115Notes

Reaction equation

HRID 51115 reaction equation
C1([S:7]([C:10]2[CH:15]=[CH:14][C:13](N)=[CH:12][CH:11]=2)(=[O:9])=[O:8])C=CC=CC=1.[Cl:17][C:18]1[C:27]2[C:22](=[CH:23][C:24]([F:29])=[C:25]([I:28])[CH:26]=2)[N:21]=[CH:20][N:19]=1>>[ClH:17].[CH:13]1[CH:12]=[CH:11][C:10]([S:7]([N:21]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:18]2[C:27]3[C:22](=[CH:23][C:24]([F:29])=[C:25]([I:28])[CH:26]=3)[N:21]=[CH:20][N:19]=2)(=[O:8])=[O:9])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 5166664-(Phenylsulfonyl)anilineHCID 219520064-Chloro-7-fluoro-6-iodoquinazoline

Product 1

HCID 68594451(4-Benzenesulphonyl)phenyl-(6-iodo-7-fluoro-quinazolin-4-yl)-amine hydrochloride

Procedure

Prepared according to Procedure A from 4-(benzenesulphonyl)phenylamine and 4-chloro-6-iodo-7-fluoroquinazoline. 1H NMR (400 MHz, DMSO-d6) δ: 10.89(s, 1H), 9.3(d, 1H), 8.79(s, 1H), 8.07(d, 2H), 8.0(d, 2H), 7.94(d, 2H), 7.67(m, 2H), 7.61(m, 2H). ESI-MS m/z 504(M−1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-bfe24bfb8e9548ef81220f26e4b60b11
Source dataset
uspto-grants-2004_03
Patent number
US06713485B2

Reaction notes

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