HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → Diethyl (3-aminophenyl)phosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | HCID 11737034 | HCID 11737034 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Diethyl (3-aminophenyl)phosphonate | HCID 284866 | 69.8% |
Reaction Steps
A solution of diethyl (3-nitrophenyl)phosphonate (520 mg, 2.0 mmol) and SnCl2 (1.8 g, 8 mmol) in EtOH (50 mL) was heated at reflux for 12 h. The mixture was then filtered and the filtrate concentrated in vacuo to yield a crude product, which was purified by preparative HPLC to afford 320 mg of desired diethyl (3-aminophenyl)phosphonate (yield: 69%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096624B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-69a09e0fb9264d17961e75600bda41d4 |
| Source note | uspto-grants-2015_08 |