Dipropan-2-yl(4-aminophenyl)phosphonate → 4-(5,5-Dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)aniline

Participants

Role	Name	HCID	Charge
Reactant	Dipropan-2-yl(4-aminophenyl)phosphonate	HCID 86653993	—
Reactant	5,5-Dimethyl-2-(4-nitrophenyl)-1,3,2-dioxaphosphinane 2-oxide	HCID 86653994	—
Product	4-(5,5-Dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)aniline	HCID 15426335	41%

Reaction Steps

Prepared according to the procedure described for dipropan-2-yl (4-aminophenyl)phosphonate using 5,5-dimethyl-2-(4-nitrophenyl)-1,3,2-dioxaphosphinane 2-oxide. Yield: 41%. 1H-NMR (DMSO-d6, 400 MHz): δ=0.97 (s, 3 H), 1.02 (s, 3 H), 3.78 (m, 2 H), 4.08 (m, 2 H), 5.91 (s, br, 2 H), 6.61 (dd, J=3.6, 8.4 Hz, 2 H), 7.34 (m, 2 H). MS: m/z 242.10 [MH+].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09096624B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-12509e46aafe4b74b095a225b92535b0
Source note	uspto-grants-2015_08