Dipropan-2-yl(4-aminophenyl)phosphonate → 3-(5,5-Dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)aniline

Participants

Role	Name	HCID	Charge
Reactant	Dipropan-2-yl(4-aminophenyl)phosphonate	HCID 86653993	—
Reactant	5,5-Dimethyl-2-(3-nitrophenyl)-1,3,2-dioxaphosphinane 2-oxide	HCID 86653996	—
Product	3-(5,5-Dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)aniline	HCID 86653995	63%

Reaction Steps

Prepared according to the procedure described for dipropan-2-yl (4-aminophenyl)phosphonate using 5,5-dimethyl-2-(3-nitrophenyl)-1,3,2-dioxaphosphinane 2-oxide. Yield: 63%. 1H-NMR (DMSO-d6, 400 MHz): δ=0.94 (s, 3 H), 1.07 (s, 3 H), 3.84 (dd, J=9.6, 10.8 Hz, 2 H), 4.07 (dd, J=11.2, 14.0 Hz, 2 H), 5.43 (s, br, 2 H), 6.75-6.78 (m, 2 H), 6.88 (d, 1 H), 7.16 (m, 1 H). MS: m/z 242.11 [MH+].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09096624B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-065d0393d93f46eebd17acd73b9a8b23
Source note	uspto-grants-2015_08