Triethyl phosphite → Diethyl(4-amino-3-methoxybenzyl)phosphonate

HRID 511230Notes

Reaction equation

HRID 511230 reaction equation
[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6]CP(=O)OCC)=[CH:4][C:3]=1[O:15][CH3:16].[CH2:17]([O:19][P:20]([O:24]CC)[O:21][CH2:22][CH3:23])[CH3:18]>>[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][P:20](=[O:24])([O:21][CH2:22][CH3:23])[O:19][CH2:17][CH3:18])=[CH:4][C:3]=1[O:15][CH3:16]

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 178476797HCID 178476797, compound

Product 1

HCID 86653997Diethyl(4-amino-3-methoxybenzyl)phosphonate

Procedure

This material was prepared according to the procedure described above for ethyl (4-amino-3-methoxybenzyl)methylphosphinate using triethylphosphite in the first step. MS (ES+): m/z 274.01 [MH+] (ZQ3, polar 5 min).

Workup

  1. customThis material was prepared
  2. customm/z 274.01 [MH+] (ZQ3, polar 5 min)

Sources & evidence

ORD record
ord-e6b7be03a167453eadd2bf0594d7113c
Source dataset
uspto-grants-2015_08
Patent number
US09096624B2

Reaction notes

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