Diethyl p-aminobenzylphosphonate → Diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

Participants

Reaction Steps

Prepared in a manner analogous to that for diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate using commercially available diethyl(4-aminobenzyl)phosphonate in place of diethyl (4-amino-3-methoxybenzyl)phosphonate. Following chromatography, the semi-pure product was crystallized from ethyl acetate to afford the title compound. 1H NMR (400 MHz, METHANOL-d4) d ppm 1.22-1.32 (m, 6 H), 3.17-3.28 (m, 2 H), 3.98-4.10 (m, 4 H), 7.30 (dd, J=8.72, 2.65 Hz, 2 H), 7.65 (d, J=7.83 Hz, 2 H), 8.63 (s, 1 H).

Provenance & Evidence