Diethyl (4-{[4-chloro-5-(trifluoromethyl) pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate → HCID 178476859, compound

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Reaction Steps

This compound was prepared in a manner analogous to Example 87 using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate and 7-amino-2-methyl-4-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-2,3-dihydro-1H-isoindol-1-one. 1H NMR (CD3OD, 400 MHz): δ=1.29 (t, J=7.07 Hz, 6 H), 1.72 (dd, J=12.76, 3.66 Hz, 2 H), 1.77-1.89 (m, 2 H), 1.92-2.04 (m, 2 H), 2.21 (d, J=12.13 Hz, 2 H), 2.81-2.91 (m, 2 H), 2.93 (s, 3 H), 3.19 (s, 3 H), 3.33-3.41 (m, 2 H), 3.45 (br. s., 3 H), 3.91 (s, 3 H), 4.05-4.15 (m, 4 H), 4.55 (s, 2 H), 6.99 (ddd, J=7.96, 2.40, 2.27 Hz, 1 H), 7.13 (t, J=2.02 Hz, 1 H), 7.45 (d, J=8.59 Hz, 1 H), 7.70 (d, J=8.08 Hz, 1 H), 8.36 (s, 1 H), 8.41 (br. s., 1 H). MS (ES+): m/z 760.30 [MH+]; HPLC: tR=1.18 minutes (UPLC TOF MS: polar—3 min).

Provenance & Evidence