2-amino-4-fluoro-N-methylbenzamide → Diethyl (4-{[4-{[5-fluoro-2-(methylcarbamoyl)phenyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate

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Reaction Steps

The title compound was prepared using the procedure from Example 102 using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate and 2-Amino-4-fluoro-N-methylbenzamide. 1H NMR (DMSO-d6, 400 MHz): δ=1.19 (t, J=7.07 Hz, 6H), 2.77 (d, J=4.55 Hz, 3 H), 3.16-3.24 (m, 2 H), 3.78 (s, 3 H), 3.92-4.01 (m, 4 H), 6.83 (d, J=7.83 Hz, 1 H), 6.93 (br. s., 1 H), 6.99 (s, 1 H), 7.53 (br. s., 1 H), 7.78 (t, J=7.33 Hz, 1 H), 8.25-8.48 (m, 2 H), 8.62-9.04 (m, 2 H), 11.86 (br. s., 1H). MS (ES+): m/z 586.18 [MH+] (TOF, polar).

Provenance & Evidence