2-Amino-5-bromo-N-methylbenzamide → Diethyl (4-{[4-{[4-bromo-2-(methylcarbamoyl)phenyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate

Participants

Role	Name	HCID	Charge
Reactant	2-Amino-5-bromo-N-methylbenzamide	HCID 50999511	—
Reactant	Diethyl (4-{[4-chloro-5-(trifluoromethyl) pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate	HCID 86654002	—
Product	Diethyl (4-{[4-{[4-bromo-2-(methylcarbamoyl)phenyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate	HCID 58293066	—

Reaction Steps

The title compound was prepared using the procedure for Example 102 with diethyl (4-{[4-chloro-5-(trifluoromethyl) pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate and Compound 106A. MS (ES+): tn/z 646.31 (100) [MH+]; HPLC: tR=1.14 min (UPLC, purity).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09096624B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-c87974e4a85c418ea25c75071da7b91e
Source note	uspto-grants-2015_08