Pyrrolidine → HCID 86654009, compound

Participants

Reaction Steps

A mixture of tert-Butyl (7-formyl-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)carbamate (Compound 109C, 23.0 mg, 0.0792 mmol) and sodium triacetoxyborohydride (101 mg, 0.475 mmol) in THF (0.5 mL) was stirred at room temperature for 20 minutes. Pyrrolidine (39.7 uL, 0.475 mmol) was added and the resulting mixture was stirred at room temperature overnight. The THF was removed in vacuo and the crude product was partitioned between EtOAc and brine. The organic layer was dried over MgSO4 and concentrated in vacuo to deliver the desired product. MS (ES+): m/z 346.32 (100) [MH+]; HPLC: tR=0.76 min (UPLC, Analytical).

Provenance & Evidence