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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 511301Generated: October 29, 2026

2-Amino-N,N-dimethylbenzamide → Diethyl (4-{[4-{[2-(dimethylcarbamoyl)phenyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

https://huagongshe.com/reaction/511301

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Amino-N,N-dimethylbenzamideHCID 4778175—
ReactantDiethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonateHCID 86654003—
ProductDiethyl (4-{[4-{[2-(dimethylcarbamoyl)phenyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonateHCID 49821269—

Reaction Steps

The title compound was prepared using the procedure for Example 102 with diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate and the commercially available 2-amino-N,N-dimethylbenzamide. MS (ES+): m/z 552.38 (100) [MH+]; HPLC: tR=0.96 min (UPLC, purity).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09096624B2
Source datasetuspto-grants-2015_08
ORD IDord-c28cbfa926ea42d1a9d87ffbe55c398f
Source noteuspto-grants-2015_08