HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bis(2-hydroxyethyl)(3-methoxy-4-nitrobenzyl)phosphonate → Bis(2-hydroxyethyl)(4-amino-3-methoxybenzyl)phosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bis(2-hydroxyethyl)(3-methoxy-4-nitrobenzyl)phosphonate | HCID 86654013 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Bis(2-hydroxyethyl)(4-amino-3-methoxybenzyl)phosphonate | HCID 86654012 | 82.4% |
Reaction Steps
A mixture of bis(2-hydroxyethyl)(3-methoxy-4-nitrobenzyl)phosphonate (Compound 133B, 1.2 g, 3.58 mmol) and 5% Pd/C (0.2 g) in EtOH (80 mL) was hydrogenated under 50 psi hydrogen pressure at 40° C. for 6 h. The reaction mixture was filtered and the filtrate was concentrated to give the desired product (0.9 g, 82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096624B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-5715090841f447b8b21939dfe5aa077c |
| Source note | uspto-grants-2015_08 |