Bis(2-hydroxyethyl)(4-amino-3-methoxybenzyl)phosphonate → Bis(2,2,2-trifluoroethyl)(4-amino-3-methoxybenzyl)phosphonate

Participants

Reaction Steps

The title compound was prepared according to the procedure for Compound 113A using bis(2,2,2-trifluoroethyl)(3-methoxy-4-nitrobenzyl)phosphonate (Compound 114B, 2.8 g, 6.81 mmol). The reaction mixture was filtered and the filtrate was concentrated to give the desired product (2 g, 77%). 1H NMR (DMSO-d6, 400 MHz): δ=3.29 (d, J=21.2 Hz, 2 H), 3.68 (s, 3 H), 4.50-4.61 (m, 4 H), 4.64 (s, br, 2 H), 6.50-6.60 (m, 2 H), 6.67 (s, 1 H).

Provenance & Evidence