2-Amino-5-fluoro-N-methylbenzamide → Diethyl (4-amino-3-fluoro-5-methoxybenzyl)phosphonate

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Reaction Steps

The title compound was prepared using the procedure from Compound 102A (2-Amino-5-fluoro-N-methylbenzamide) with Diethyl (3-fluoro-5-methoxy-4-nitrobenzyl)phosphonate (Compound 146B). 1H NMR (CDCl3, 400 MHz): δ=1.27 (t, J=7.07 Hz, 6 H), 2.99-3.08 (m, 2H), 3.87 (s, 3 H), 4.00-4.06 (m, 4 H), 6.59 (s, 1 H), 6.63 (dt, J=10.74, 2.21 Hz, 1 H). MS (ES+): m/z 292.06 [MH+] (TOF, polar).

Provenance & Evidence