2-Amino-5-fluoro-N-methylbenzamide → Diethyl (4-amino-2-fluoro-3-methoxybenzyl)phosphonate

Participants

Reaction Steps

The title compound was prepared using the procedure from Compound 102A (2-Amino-5-fluoro-N-methylbenzamide) with Diethyl (2-fluoro-3-methoxy-4-nitrobenzyl)phosphonate (Compound 147B). 1H NMR (CDCl3, 400 MHz): δ=1.29 (t, J=6.95 Hz, 6 H), 3.13-3.21 (m, 2 H), 3.93 (d, J=1.52 Hz, 3 H), 4.04-4.12 (m, 4 H), 6.55 (d, J=8.34 Hz, 1 H), 6.83 (td, J=7.96, 2.78 Hz, 1 H). MS (ES+): m/z 292.11 [MH+] (TOF, polar).

Provenance & Evidence