4-(4-Fluoro-benzyloxy)-phenylamine → (6-Chloropyrido[3,4-d]pyrimidin-4-yl)-(4-(4-fluorobenzyloxy)-phenyl)-amine

HRID 51136Notes

Reaction equation

HRID 51136 reaction equation
Cl[C:2]1[C:3]2[CH:11]=[C:10]([Cl:12])[N:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[F:13][C:14]1[CH:28]=[CH:27][C:17]([CH2:18][O:19][C:20]2[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][CH:21]=2)=[CH:16][CH:15]=1>C(#N)C>[Cl:12][C:10]1[N:9]=[CH:8][C:4]2[N:5]=[CH:6][N:7]=[C:2]([NH:24][C:23]3[CH:22]=[CH:21][C:20]([O:19][CH2:18][C:17]4[CH:27]=[CH:28][C:14]([F:13])=[CH:15][CH:16]=4)=[CH:26][CH:25]=3)[C:3]=2[CH:11]=1

Participants

4

Reactant 2

HCID 64860214-(4-Fluoro-benzyloxy)-phenylamineHCID 108218764,6-Dichloropyrido[3,4-d]pyrimidine

Product 1

HCID 21952330(6-Chloropyrido[3,4-d]pyrimidin-4-yl)-(4-(4-fluorobenzyloxy)-phenyl)-amine

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

4,6-Dichloro-pyrido[3,4-d]pyrimidine (1 g) and 4-(4-fluorobenzyloxy)aniline (1.08 g) in acetonitrile (70 ml) were reacted together as in Procedure A. The product was collected by filtration as a yellow solid (1.83 g); m/z 381 (M+1)+.

Workup

  1. filtrationThe product was collected by filtration as a yellow solid (1.83 g)

Sources & evidence

ORD record
ord-2256458f1ee44b3e80576fb6914af416
Source dataset
uspto-grants-2004_03
Patent number
US06713485B2

Reaction notes

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