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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 511376Generated: October 28, 2026

2-Amino-5-fluoro-N-methylbenzamide → 2-amino-6-fluoro-N-methylbenzamide

https://huagongshe.com/reaction/511376

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Amino-5-fluoro-N-methylbenzamideHCID 43132558—
Reactant2-fluoro-N-methyl-6-nitrobenzamideHCID 67255708—
Product2-amino-6-fluoro-N-methylbenzamideHCID 20806794—

Reaction Steps

The title compound was prepared according to the procedure for Compound 102A (2-Amino-5-fluoro-N-methylbenzamide) using 2-fluoro-N-methyl-6-nitrobenzamide (Compound 155B). 1H NMR (CDCl3, 400 MHz): δ=2.99 (dd, J=4.80, 1.26 Hz, 3 H), 6.35 (ddd, J=12.88, 8.08, 1.01 Hz, 1 H), 6.44-6.49 (m, 1 H), 7.09 (td, J=8.21, 6.57 Hz, 1 H). MS (ES+): m/z 169.08 [MH+] (TOF, polar).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09096624B2
Source datasetuspto-grants-2015_08
ORD IDord-8e56aec412594c2181754f7cfa29fcd2
Source noteuspto-grants-2015_08