(2-Aminophenyl)(4-methylpiperazin-1-yl)methanone → HCID 58293069, compound

HRID 511406Notes

Reaction equation

HRID 511406 reaction equation
Cl[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][N:5]=[C:4]([NH:12][C:13]2[CH:27]=[CH:26][C:16]([CH2:17][P:18](=[O:25])([O:22][CH2:23][CH3:24])[O:19][CH2:20][CH3:21])=[CH:15][CH:14]=2)[N:3]=1.[NH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[C:35]([N:37]1[CH2:42][CH2:41][N:40]([CH3:43])[CH2:39][CH2:38]1)=[O:36]>>[CH3:43][N:40]1[CH2:39][CH2:38][N:37]([C:35]([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=2[NH:28][C:2]2[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][N:5]=[C:4]([NH:12][C:13]3[CH:27]=[CH:26][C:16]([CH2:17][P:18](=[O:25])([O:19][CH2:20][CH3:21])[O:22][CH2:23][CH3:24])=[CH:15][CH:14]=3)[N:3]=2)=[O:36])[CH2:42][CH2:41]1

Participants

3

Reactant 2

HCID 550840(2-Aminophenyl)(4-methylpiperazin-1-yl)methanoneHCID 86654003Diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

Product 1

HCID 58293069HCID 58293069, compound

Procedure

The title product was prepared according to the procedure for Example 102 using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate and the commercially available (2-aminophenyl)-(4-methylpiperazin-1-yl)methanone. MS (ES+): m/z 607.37 (100) [MH+]; HPLC: tR=0.66 min (UPLC, purity).

Sources & evidence

ORD record
ord-835d01d21ef04ec0a23d6987a3046a95
Source dataset
uspto-grants-2015_08
Patent number
US09096624B2

Reaction notes

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