HRID511407

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID713136

(2-Aminophenyl)(pyrrolidin-1-yl)methanone

C11H14N2O

结构：CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Cl)n2)c(OC)c1)OCC

HCID86654002

未命名化合物

PRODUCTS

生成物

结构：CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccccc3C(=O)N3CCCC3)n2)c(OC)c1)OCC

HCID58292909

未命名化合物

PROCEDURE

实验过程

The title product was prepared according to the procedure for Example 102 using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate and the commercially available 2-(pyrrolidin-1-ylcarbonyl)aniline.MS (ES+): m/z 608.35 (100) [MH+]; HPLC: tR=1.07 min (UPLC, purity).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b5c040df714c4bf4b3378121a2087d9a
来源数据集: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09096624B2
来源说明: uspto-grants-2015_08

反应 SMILES

Cl[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][N:5]=[C:4]([NH:12][C:13]2[CH:27]=[CH:26][C:16]([CH2:17][P:18](=[O:25])([O:22][CH2:23][CH3:24])[O:19][CH2:20][CH3:21])=[CH:15][C:14]=2[O:28][CH3:29])[N:3]=1.[N:30]1([C:35]([C:37]2[CH:43]=[CH:42][CH:41]=[CH:40][C:38]=2[NH2:39])=[O:36])[CH2:34][CH2:33][CH2:32][CH2:31]1>>[CH3:29][O:28][C:14]1[CH:15]=[C:16]([CH:26]=[CH:27][C:13]=1[NH:12][C:4]1[N:3]=[C:2]([NH:39][C:38]2[CH:40]=[CH:41][CH:42]=[CH:43][C:37]=2[C:35]([N:30]2[CH2:34][CH2:33][CH2:32][CH2:31]2)=[O:36])[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][N:5]=1)[CH2:17][P:18](=[O:25])([O:22][CH2:23][CH3:24])[O:19][CH2:20][CH3:21]