7-Amino-4-methoxy-2-methyl-2,3-dihydroisoindol-1-one → Diethyl [4-({4-[(7-methoxy-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)benzyl]phosphonate

Participants

Role	Name	HCID	Charge
Reactant	7-Amino-4-methoxy-2-methyl-2,3-dihydroisoindol-1-one	HCID 67253941	—
Reactant	Diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate	HCID 86654003	—
Product	Diethyl [4-({4-[(7-methoxy-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)benzyl]phosphonate	HCID 58293007	—

Reaction Steps

The title compound was prepared according to the procedure for Example 102 using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate and 7-Amino-4-methoxy-2-methyl-2,3-dihydro-1H-isoindol-1-one (Compound 205A). MS (ES+): m/z 581.20 (100) [MH+]; HPLC: tR=1.08 min (UPLC, purity).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09096624B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-65a4c8b20986497e86f26fda367e44ce
Source note	uspto-grants-2015_08