4-Methoxy-2-methyl-7-nitro-2,3-dihydro-isoindol-1-one → 4-Ethoxy-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one

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Reaction Steps

The title compound was prepare according to the procedure for 4-Methoxy-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one (Compound 205B) using 4-Hydroxy-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one and iodoethane (Compound 205C, 28.8 uL, 0.360 mmol). 1H NMR (400 MHz, CD3OD) δ=1.47 (t, J=7.1 Hz, 3 H), 3.17 (s, 3 H), 4.27 (q, J=6.9 Hz, 2 H), 4.43 (s, 2 H), 7.23 (d, J=8.8 Hz, 1 H), 7.90 (d, J=8.8 Hz, 1H). MS (ES+): m/z 251.21 (100) [MH+]; HPLC: tR=1.06 min (UPLC, Analytical).

Provenance & Evidence