HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl iodide → 2-Methyl-7-nitro-4-(propan-2-yloxy)-2,3-dihydro-1H-isoindol-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | 4-Methoxy-2-methyl-7-nitro-2,3-dihydro-isoindol-1-one | HCID 59849179 | — |
| Reactant | 4-Hydroxy-2-methyl-7-nitro-2,3-dihydro-isoindol-1-one | HCID 59849205 | — |
| Product | 2-Methyl-7-nitro-4-(propan-2-yloxy)-2,3-dihydro-1H-isoindol-1-one | HCID 67254762 | — |
Reaction Steps
The title compound was prepare according to the procedure for 4-Methoxy-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one (Compound 205B) using 4-Hydroxy-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one and 4-Hydroxy-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one (Compound 205C, 50.0 mg, 0.240 mmol) and isopropyl iodide. 1H NMR (400 MHz, CD3OD) δ=1.40 (d, J=6.1 Hz, 6 H), 3.15 (s, 3 H), 4.37 (s, 2 H), 4.80-4.87 (m, 1 H), 7.22 (d, J=8.8 Hz, 1 H), 7.86 (d, J=8.8 Hz, 1 H). MS (ES+): m/z 237.18 (100) [MH+]; HPLC: tR=0.94 min (UPLC, Analytical).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096624B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-b6552d398aac48b4938d917f955b4373 |
| Source note | uspto-grants-2015_08 |