HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 511449Generated: October 27, 2026
Morpholine → 2-Methyl-4-(morpholin-4-yl)-7-nitro-2,3-dihydro-1H-isoindol-1-one
https://huagongshe.com/reaction/511449
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Bromo-2-methyl-7-nitroisoindolin-1-one | HCID 53407894 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Methyl-4-(morpholin-4-yl)-7-nitro-2,3-dihydro-1H-isoindol-1-one | HCID 67254062 | — |
Reaction Steps
A mixture of 4-Bromo-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one (100.0 mg, 0.3689 mmol), morpholine (321.7 uL, 3.689 mmol), DIPEA (642.6 uL, 3.689 mmol) in DMF (4 mL) were mixed in sealed tube under an atmosphere of argon and heated at 90° C. for 4 days. The crude material was purified by MDP directly under basic conditions the desired product. MS (ES+): m/z 278.24 (100) [MH+]; HPLC: tR=0.81 min (UPLC, analytical).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09096624B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-5c40a8e69fe440a9bab904050df8f8ff |
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| Source note | uspto-grants-2015_08 |
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