HRID511451

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67254860

未命名化合物

2 次

结构：CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Cl)n2)c(OC)c1)OCC

HCID86654002

未命名化合物

PRODUCTS

生成物

结构：CCOc1ccc(Nc2nc(Nc3ccc(CP(=O)(OCC)OCC)cc3OC)ncc2C(F)(F)F)c2c1CN(C)C2=O

HCID58292977

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the procedure for Example 102 using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate and 7-Amino-4-ethoxy-2-methyl-2,3-dihydro-1H-isoindol-1-one (Compound 206A). MS (ES+): m/z 624.28 (100) [MH+]; HPLC: tR=1.16 min (UPLC, purity).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-232e567c1f90487383b19557b122dc3d
来源数据集: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09096624B2
来源说明: uspto-grants-2015_08

反应 SMILES

Cl[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][N:5]=[C:4]([NH:12][C:13]2[CH:27]=[CH:26][C:16]([CH2:17][P:18](=[O:25])([O:22][CH2:23][CH3:24])[O:19][CH2:20][CH3:21])=[CH:15][C:14]=2[O:28][CH3:29])[N:3]=1.[NH2:30][C:31]1[CH:32]=[CH:33][C:34]([O:42][CH2:43][CH3:44])=[C:35]2[C:39]=1[C:38](=[O:40])[N:37]([CH3:41])[CH2:36]2>>[CH2:43]([O:42][C:34]1[CH:33]=[CH:32][C:31]([NH:30][C:2]2[C:7]([C:8]([F:9])([F:11])[F:10])=[CH:6][N:5]=[C:4]([NH:12][C:13]3[CH:27]=[CH:26][C:16]([CH2:17][P:18](=[O:25])([O:19][CH2:20][CH3:21])[O:22][CH2:23][CH3:24])=[CH:15][C:14]=3[O:28][CH3:29])[N:3]=2)=[C:39]2[C:35]=1[CH2:36][N:37]([CH3:41])[C:38]2=[O:40])[CH3:44]