反应详情

The title compound was prepared according the procedure for 2-Amino-5-fluoro-N-methylbenzamide (Compound 102A) using 2-methoxyethyl (3-methoxy-4-nitrobenzyl)methylphosphinate (Compound 216B). 1H NMR (CDCl3, 400 MHz): δ=1.39 (d, J=13.64 Hz, 3 H), 3.10 (d, J=17.43 Hz, 2 H), 3.39 (s, 3 H), 3.54-3.59 (m, 2 H), 3.87 (s, 3 H), 4.09-4.14 (m, 2 H), 6.66-6.71 (m, 1 H), 6.76-6.79 (m, 1 H), 6.80 (t, J=1.89 Hz, 1 H). MS (ES+): m/z 274.11 [MH+] (TOF, polar).