tert-Butyl (piperazin-1-yl)acetate → HCID 58292967, compound

HRID 511463Notes

Reaction equation

Br[C:2]1[CH:3]=[CH:4][C:5]([NH:13][C:14]2[C:19]([C:20]([F:23])([F:22])[F:21])=[CH:18][N:17]=[C:16]([NH:24][C:25]3[CH:39]=[CH:38][C:28]([CH2:29][P:30](=[O:37])([O:34][CH2:35][CH3:36])[O:31][CH2:32][CH3:33])=[CH:27][CH:26]=3)[N:15]=2)=[C:6]2[C:10]=1[CH2:9][N:8]([CH3:11])[C:7]2=[O:12].[C:40]([O:44][C:45](=[O:53])[CH2:46][N:47]1[CH2:52][CH2:51][NH:50][CH2:49][CH2:48]1)([CH3:43])([CH3:42])[CH3:41]>>[CH2:35]([O:34][P:30]([CH2:29][C:28]1[CH:27]=[CH:26][C:25]([NH:24][C:16]2[N:15]=[C:14]([NH:13][C:5]3[CH:4]=[CH:3][C:2]([N:50]4[CH2:49][CH2:48][N:47]([CH2:46][C:45]([O:44][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:53])[CH2:52][CH2:51]4)=[C:10]4[C:6]=3[C:7](=[O:12])[N:8]([CH3:11])[CH2:9]4)[C:19]([C:20]([F:21])([F:22])[F:23])=[CH:18][N:17]=2)=[CH:39][CH:38]=1)([O:31][CH2:32][CH3:33])=[O:37])[CH3:36]

Participants

Reactant 2

HCID 2757326tert-Butyl (piperazin-1-yl)acetate

HCID 58292897Diethyl [4-({4-[(7-bromo-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)amino]-5(trifluoromethyl)pyrimidin-2-yl}amino)benzyl]phosphonate

Product 1

HCID 58292967HCID 58292967, compound

Procedure

The title compound was prepared according to the procedure for Example 199 using Diethyl [4-({4-[(7-bromo-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)amino]-5-(trifluoromethyl) pyrimidin-2-yl}amino)benzyl]phosphonate and piperazine-1-acetic acid tert-butyl ester. MS (ES+): m/z 748.41 (100) [MH+]; HPLC: tR=0.85 min (UPLC, purity).

Sources & evidence

ORD record: ord-1f5ce2221b0c41ba95eef74483357401
Source dataset: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09096624B2

Reaction notes

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