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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 511465Generated: October 31, 2026

3-Hydroxyazetidine → HCID 58293064, compound

https://huagongshe.com/reaction/511465

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-HydroxyazetidineHCID 1514290—
ReactantDiethyl [4-({4-[(7-bromo-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)amino]-5(trifluoromethyl)pyrimidin-2-yl}amino)benzyl]phosphonateHCID 58292897—
ProductHCID 58293064HCID 58293064—

Reaction Steps

The title compound was prepared according to the procedure for Example 199 using Diethyl [4-({4-[(7-bromo-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)amino]-5-(trifluoromethyl) pyrimidin-2-yl}amino)benzyl]phosphonate and 3-hydroxyazetidine. MS (ES+): m/z 621.25 (100) [MH+]; HPLC: tR=0.89 min (UPLC, purity).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09096624B2
Source datasetuspto-grants-2015_08
ORD IDord-221722fcf23f4d589f7a36f5a8401e2a
Source noteuspto-grants-2015_08