7-amino-4-[4-(dimethylamino)cyclohexyl]-2-methyl-2,3-dihydro-1H-isoindol-1-one → Diethyl (4-{[4-({7-[4-(dimethylamino)cyclohexyl]-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate

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Reaction Steps

The title compound was prepared according to the procedure for Example 102 using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate and 7-amino-4-[4-(dimethylamino)cyclohexyl]-2-methyl-2,3-dihydro-1H-isoindol-1-one (Compound 233A). 1H NMR (CD3OD, 400 MHz): δ=1.30 (t, J=7.07 Hz, 6 H), 1.75-1.85 (m, 2 H), 1.85-2.02 (m, 4 H), 2.39 (d, J=14.15 Hz, 2 H), 2.77-2.88 (m, 1 H), 3.04 (s, 6 H), 3.18 (s, 3 H), 3.38-3.50 (m, 3 H), 3.86 (s, 3 H), 4.07-4.20 (m, 4 H), 4.51 (s, 2 H), 7.01-7.07 (m, 1 H), 7.12 (t, J=2.15 Hz, 1 H), 7.62 (d, J=8.59 Hz, 2 H), 8.32-8.42 (m, 2 H). MS (ES+): m/z 705.26 [MH+] (TOF, polar).

Provenance & Evidence