1-Acetylpiperazine → 4-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-7-amino-2-methyl-2,3-dihydro-1H-isoindol-1-one

Participants

Role	Name	HCID	Charge
Reactant	1-Acetylpiperazine	HCID 83795	—
Reactant	7-amino-4-[4-(dimethylamino)cyclohexyl]-2-methyl-2,3-dihydro-1H-isoindol-1-one	HCID 67254285	—
Reactant	7-amino-2-methyl-4-(4-oxocyclohexyl)-2,3-dihydro-1H-isoindol-1-one	HCID 67256125	—
Product	4-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-7-amino-2-methyl-2,3-dihydro-1H-isoindol-1-one	HCID 67256455	—

Reaction Steps

The title product was prepared according to the procedure for Compound 233A using 7-amino-2-methyl-4-(4-oxocyclohexyl)-2,3-dihydro-1H-isoindol-1-one and 1-acetylpiperazine. 1H NMR (CDCl3, 400 MHz): δ=1.80-1.98 (m, 3 H), 2.01-2.14 (m, 6 H), 2.25 (d, J=19.20 Hz, 1 H), 2.42-2.62 (m, 5 H), 3.12-3.17 (m, 3 H), 3.45-3.70 (m, 4 H), 4.28-4.33 (m, 2 H), 5.10 (br. s., 2 H), 6.58 (d, J=8.08 Hz, 1 H), 7.17 (d, J=8.34 Hz, 1 H). MS (ES+): m/z 371.26 [MH+] (TOF, polar).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09096624B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-8b8eab4228b44d3d994097f83b0c4681
Source note	uspto-grants-2015_08