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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 511488Generated: October 29, 2026

Pyrrolidine → 7-amino-2-methyl-4-[4-(pyrrolidin-1-yl)cyclohexyl]-2,3-dihydro-1H-isoindol-1-one

https://huagongshe.com/reaction/511488

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPyrrolidineHCID 31268—
Reactant7-amino-4-[4-(dimethylamino)cyclohexyl]-2-methyl-2,3-dihydro-1H-isoindol-1-oneHCID 67254285—
Reactant7-amino-2-methyl-4-(4-oxocyclohexyl)-2,3-dihydro-1H-isoindol-1-oneHCID 67256125—
Product7-amino-2-methyl-4-[4-(pyrrolidin-1-yl)cyclohexyl]-2,3-dihydro-1H-isoindol-1-oneHCID 67256340—

Reaction Steps

The title product was prepared according to the procedure for Compound 233A using 7-amino-2-methyl-4-(4-oxocyclohexyl)-2,3-dihydro-1H-isoindol-1-one and pyrrolidine. Product used crude in the next step.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09096624B2
Source datasetuspto-grants-2015_08
ORD IDord-f4d900e26536400eacc06840a172712b
Source noteuspto-grants-2015_08