Hydrochloric Acid → HCID 86654061, compound

Participants

Reaction Steps

A solution of (3-Methyl-5-nitro-4-oxo-4H-quinolin-1-ylmethyl)-phosphonic acid diethyl ester (Compound 303B, 20 mg; 0.05 mmol) in methanol (5 mL) was charged with Pd/C (5 mg) and 1M HCl in ether (1 mL) under nitrogen and stirred under 1 atmosphere of hydrogen overnight at RT. The solution was filtered the filtrate concentrated to get the final compound (yield 20 mg; 99%; tlc 1:9 MeOH:DCM); 1H NMR (300 MHz, CDCl3), δ ppm, 8.12 (s, 1H), 8.01 (d, 6Hz, 1H,) 7.88-7.83 (m, 1H) 7.40 (d, J=9Hz, 1H) 4.12-4.13 (m, 4H,) 3.31-3.29 (m, 2H), 2.14 (s, 3H), 1.27-1.25 (m, 6H)

Provenance & Evidence