2-Amino-5-fluoro-N-methylbenzamide → HCID 178472348, compound

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Reaction Steps

The title compound was prepared according to Compound 102A using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate (233.0 mg, 0.44 mmol) and ethyl trans-4-(5-amino-3-methyl-4-oxo-1,4-dihydroquinolin-8-yl)cyclohexanecarboxylate (Compound 304A, 172.0 mg, 0.52 mmol). 1H NMR (400 MHz, MeOD) δ ppm 1.26-1.35 (m, 9H) 1.69-1.94 (m, 6 H) 2.14 (s, 3 H) 2.31 (d, J=13.64 Hz, 2 H) 2.83 (br. s., 1 H) 2.97-3.06 (m, 1 H) 3.33 (s, 1 H) 3.39 (s, 1 H) 3.91 (s, 3 H) 4.10 (quin, J=7.26 Hz, 4 H) 4.24 (q, J=7.24 Hz, 2 H) 6.93 (m, J=6.06 Hz, 1 H) 7.11 (t, J=2.02 Hz, 1 H) 7.35 (d, J=7.83 Hz, 1 H) 7.81 (d, J=7.83 Hz, 1 H) 7.87 (s, 1 H) 8.31 (s, 1 H) 8.49 (br. s., 1 H). MS (ES+): m/z: 746.20/747.19 (100/40) [MH+]. HPLC: tR=4.42 min (Micromass ZQ3: polar—5 min).

Provenance & Evidence