HCID 67776491, compound → HCID 178491012, compound

Participants

Reaction Steps

N-(2-amino-4-(trifluoromethyl)phenyl)-3-(3-((((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(methyl)amino)cyclobutyl)propanamide (0.38 g, 0.50 mmol) and Acetic acid (5 ml) were stirred overnight at 65° C. The volatiles were removed in vacuo and remaining water was removed by azeotropic distillation with ethanol followed by 1 hour on high vacuum. The resulting residue was partitioned between NaHCO3 (saturated) and DCM. The aqueous layer was extracted (3×) and combined organics were dried with MgSO4, filtered, concentrated and then purified by flash chromatography (DCM/7N NH3 in MeOH 93:7) to yield an off white foam.

Provenance & Evidence