N-(2-amino-4-(trifluoromethoxy)phenyl)-3-(3-((((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutyl)propanamide → HCID 178491017, compound

HRID 511662Notes

Reaction equation

HRID 511662 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:4][C:3]=1[NH:13][C:14](=O)[CH2:15][CH2:16][CH:17]1[CH2:20][CH:19]([N:21]([CH2:25][C@@H:26]2[C@@H:33]3[C@@H:29]([O:30][C:31]([CH3:35])([CH3:34])[O:32]3)[C@H:28]([N:36]3[C:40]4[N:41]=[CH:42][N:43]=[C:44]([NH:45][CH2:46][C:47]5[CH:52]=[CH:51][C:50]([O:53][CH3:54])=[CH:49][C:48]=5[O:55][CH3:56])[C:39]=4[CH:38]=[CH:37]3)[CH2:27]2)[CH:22]([CH3:24])[CH3:23])[CH2:18]1>CC(O)=O>[CH3:56][O:55][C:48]1[CH:49]=[C:50]([O:53][CH3:54])[CH:51]=[CH:52][C:47]=1[CH2:46][NH:45][C:44]1[C:39]2[CH:38]=[CH:37][N:36]([C@H:28]3[C@H:29]4[C@H:33]([O:32][C:31]([CH3:34])([CH3:35])[O:30]4)[C@@H:26]([CH2:25][N:21]([CH:22]([CH3:23])[CH3:24])[CH:19]4[CH2:20][CH:17]([CH2:16][CH2:15][C:14]5[NH:13][C:3]6[CH:4]=[CH:5][C:6]([O:8][C:9]([F:11])([F:10])[F:12])=[CH:7][C:2]=6[N:1]=5)[CH2:18]4)[CH2:27]3)[C:40]=2[N:41]=[CH:42][N:43]=1

Participants

3

Reactant 1

HCID 67774050N-(2-amino-4-(trifluoromethoxy)phenyl)-3-(3-((((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutyl)propanamide

Product 1

HCID 178491017HCID 178491017, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

N-(2-amino-4-(trifluoromethoxy)phenyl)-3-(3-((((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutyl)propanamide (1.4 g, 1.8 mmol) was heated in AcOH at 60° C. overnight. The reaction mixture was concentrated in vacuo giving the crude product.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-b94e11a226fa4abcaa62569db0a92348
Source dataset
uspto-grants-2015_08
Patent number
US09096634B2

Reaction notes

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