HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 511666Generated: October 25, 2026
Hydrazine → 2-Nitro-4-(oxetan-3-YL)aniline
https://huagongshe.com/reaction/511666
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | N-(2-nitro-4-(oxetan-3-yl)phenyl)acetamide | HCID 67776164 | — |
| Product | 2-Nitro-4-(oxetan-3-YL)aniline | HCID 67775173 | 69.1% |
Reaction Steps
A suspension of N-(2-nitro-4-oxetan-3-ylphenyl)acetamide (125 mg, 0.529 mmo) in aqueous hydrazine (8 ml, 160 mmol) was heated at 70° C. for 2 h, the reaction mixture was cooled to 45° C. and the hydrazine was removed in vacuo to yield a solid. The crude material was purified by flash chromatography (SiO2, eluting with 20% EtOAc/CH2Cl2 to yield the desired product (71 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09096634B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-5f0508cb6a344463b80dce75f9d7ab4e |
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| Source note | uspto-grants-2015_08 |
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