2-Thiophenecarboxaldehyde → 2-[N-(Thien-2-ylmethylene)amino]-4-methylpentanoic acid, tert-butyl ester

HRID 51168Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 51168
[C:1]([O:5][C:6](=[O:13])[C@H:7]([CH2:9][CH:10]([CH3:12])[CH3:11])[NH2:8])([CH3:4])([CH3:3])[CH3:2].[S:14]1[CH:18]=[CH:17][CH:16]=[C:15]1[CH:19]=O>C1(C)C=CC=CC=1>[C:1]([O:5][C:6](=[O:13])[CH:7]([N:8]=[CH:19][C:15]1[S:14][CH:18]=[CH:17][CH:16]=1)[CH2:9][CH:10]([CH3:11])[CH3:12])([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 73642-ThiophenecarboxaldehydeHCID 7022311tert-butyl (2S)-2-amino-4-methylpentanoate

Produkt 1

HCID 227370202-[N-(Thien-2-ylmethylene)amino]-4-methylpentanoic acid, tert-butyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a stirred solution of leucine t-butyl ester (10 g) in toluene (100 mL) is added thiophene-2-carboxaldehyde (5.0 mL) and the mixture is heated to 90° C. for 2 hours. The mixture was cooled, washed with water, dried over magnesium sulfate, filtered, and evaporated to an oil (14.5 g).

Aufarbeitung

  1. temperatureThe mixture was cooled
  2. washwashed with water
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated to an oil (14.5 g)

Quellen und Nachweise

ORD-Eintrag
ord-c3a5ba875d2842dc9062b451251de812
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06713502B2

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