Sulfuric Acid → Salicylic Acid

Participants

Reaction Conditions

Reaction Steps

While 100 g of 2,5-dihydroxybenzoic acid and 1441 g of 80% sulfuric acid were heated to 50° C., these were mixed. 144 g of tert-butyl alcohol was added to the mixed solution, and stirred at 50° C. for 30 minutes. Next, the operation was performed 3 times in which 144 g of tert-butyl alcohol was added to the mixed solution, and stirred at 50° C. for 30 minutes. The reaction solution was cooled to room temperature. The reaction solution was gradually poured into 1.00 kg of ice water, and a precipitate was filtered. The precipitate was washed with water, and further washed with hexane. The precipitate obtained here was dissolved in 200 mL of methanol, and again precipitated in 3.60 L of water. After filtration, the obtained product was dried at 80° C. to obtain 74.9 g of a salicylic acid intermediate product represented by the following formula (7).

Provenance & Evidence