1-(Triphenylphosphoranylidene)acetone → HCID 67516599, compound

Participants

Reaction Steps

1.87 g (4.65 mmol) of 6-(benzyloxy)-5-(2,6-diethyl-4-methylphenyl)-4-oxo-1,2,3,3a,4,6a-hexahydropentalene-2-carbaldehyde (compound I-a-2) and 1.63 g (5.11 mmol) of acetonylidenetriphenylphosphorane in 40 ml of trichloromethane are stirred at room temperature for 12 h. The solvent is then removed, and the residue is purified chromatographically on silica gel (mobile phase ethyl acetate/hexane 1:5). This gives 1.37 g (66%) of 3-benzyloxy-2-(2,6-diethyl-4-methylphenyl)-5-(3-oxobut-1-enyl)-4,5,6,6a-tetrahydro-3aH-pentalen-1-one as a colourless oil.

Provenance & Evidence