Triethylamine → HCID 87429621, compound

Participants

Reaction Steps

267 mg (0.82 mmol) of 2-(2,6-diethyl-4-methylphenyl)-5-(oxobutyl)-tetrahydropentalene-1,3-dione (example I-a-39), 102 mg (1.23 mmol) of O-methylhydroxylamine hydrochloride and 0.5 ml of triethylamine in 10 ml of acetonitrile are stirred at room temperature overnight. The mixture is then taken up in ethyl acetate, washed with water and dried (magnesium sulphate) and the solvent is distilled off Chromatography on silica gel (mobile phase ethyl acetate/hexane 1:4) gives 225 mg (77%) of the target compound in the form of colourless crystals of m.p. 79-80° C.

Provenance & Evidence