Trimethylamine → HCID 86702741, compound

Participants

Reaction Steps

At room temperature, 80 mg (0.80 mmol) of trimethylamine are added dropwise to 0.090 g (0.25 mmol) of 2-(2,6-diethyl-4-methylphenyl)-5-(dimethoxymethyl)-3-hydroxy-4,5,6,6a-tetrahydropentalen-1(3aH)-one (compound I-a-9 according to the invention) and 30 mg (0.28 mmol) of ethyl chloroformate in 15 ml of dichloromethane, and the mixture is stirred for another 1 h. The mixture is poured onto ice-water, taken up in dichloromethane, washed with water, dried (magnesium sulphate), and the solvent is distilled off.

Provenance & Evidence