Thionyl Chloride → HCID 23123740, compound

HRID 511756Notes

Reaction equation

HRID 511756 reaction equation
[Cl:1][C:2]([Cl:18])([Cl:17])[CH2:3][O:4][C:5]([NH:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11](O)=[O:12])=[O:6].S(Cl)([Cl:21])=O>C1(C)C=CC=CC=1>[Cl:1][C:2]([Cl:18])([Cl:17])[CH2:3][O:4][C:5]([NH:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11]([Cl:21])=[O:12])=[O:6]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 23123812HCID 23123812, compound

Product 1

HCID 23123740HCID 23123740, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a toluene solution (10 ml) of 1.0 g of 3-[(2,2,2-trichloroethoxy)carbonylamino]benzoic acid produced in Example 9-1 was added 2 ml of thionyl chloride, and the resultant mixture was stirred at 100° C. The solvent was distilled off under reduced pressure, and the residue was dissolved in toluene. The solvent was again distilled off under reduced pressure to obtain 1.0 g (yield 95%) of the title compound as a solid.

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. dissolutionthe residue was dissolved in toluene
  3. distillationThe solvent was again distilled off under reduced pressure

Sources & evidence

ORD record
ord-8198fd1df6f8403fa919b331450553e7
Source dataset
uspto-grants-2015_08
Patent number
US09101135B2

Reaction notes

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