Lithium Hexamethyldisilazide → Hexamethyldisilazane

Participants

Reaction Steps

Compound 1G (1.48 g, 3.53 mmol) in THF (15 mL) was cooled to −78° C. under nitrogen. A solution of 1 M LiHMDS solution in THF (3.6 mL, 3.6 mmol) was added slowly at −78° C. Upon completion of the addition, the reaction flask was allowed to warm to room temperature. After stirring at room temperature for 16 h, the reaction mixture was concentrated under vacuum and hexane (20 mL) was added. The precipitated lithium salts were filtered off through a Celite pad, rinsed with additional hexane and the combined filtrates were concentrated under vacuum to give crude bis(trimethylsilyl)amine product 1H (3.5 mmol).

Provenance & Evidence