Ethyl Acetate → HCID 68158303, compound

Participants

Reaction Steps

A solution of 5-(bromomethyl)-1-methyl-4-nitro-1H-imidazole-2-carbonitrile (264) (70 mg, 0.29 mmol) in 90% H2SO4 (1 mL) was heated at 65-70° C. for 1 hour, before being diluted with water and given a standard ethyl acetate workup to give 5-(bromomethyl)-1-methyl-4-nitro-1H-imidazole-2-carboxamide (266) (67 mg, 84%), as white solid, m.p. 220-222° C. 1H NMR [(CD3)2SO] δ 8.18 (s, 1H), 7.87 (s, 1H), 5.05 (s, 2H), 4.02 (s, 3H). HR-MS (APC+, 79/81Br) found: m/z 262.9770/264.9752 (M+1), calcd. for C6H879/81BrN4O3+: 262.9774/264.9754.

Provenance & Evidence