Hydrochloric Acid → HCID 67289220, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of 4-Imidazol-1-ylmethyl-indole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methy ester (350 mg, 0.99 mmol) and 2N aqueous sodium hydroxide solution (1 mL. 2 mmol) in THF (5 mL) was refluxed at 80° C. with stirring for 2 days. 2N hydrochloric acid was added until pH was 7.0. The mixture was concentrated in vacuo. The resulting percipitate was collected by filtration and washed with dichloromethane, methanol, H2O and ethyl acetate to give 63 mg (27% yield) of the title compound as a white solid:

Provenance & Evidence